As a transcription factor, the c-Myc protein regulates a variety of cellular processes including cell growth and proliferation, cell-cycle progression, transcription, differentiation, apoptosis and cellular motility48 and knockdown of c-Myc by siRNA or some of its effectors, miRNAs, can significantly reduce cancer cell growth and increase the apoptosis in vitro and suppresses tumorigenicity in vivo44. Here, MYC is linked to cancer.