CASP8 and systemic inflammatory response syndrome: Thus, we measured the concentration of SIRS-related cytokines in the media of necroptotic and non-necroptotic cell cultures and found that, in spite of the 50% necrosis induced by caspase-8 inhibition, the levels of pro-inflammatory IL-1β decreased significantly when monocytes were pre-treated with IETD-fmk prior to LPS challenge (Figure 3a).