TNF-α-induced protein 3-interacting protein 1 (TNIP1) on chromosome 5q33, also known as VAN, NAF1, ABIN-1, and nip40-1, encodes an A20-binding protein which plays an important role in autoimmunity, chronic inflammation, and cancer through the inhibition of nuclear factor kappa-B (NF-κB) activation [8]. This evidence concerns the gene NFKB1 and cancer.