We also identified pontin/RUVBL1 a gene which is upregulated by AML1-ETO and generated by one of the most frequent chromosomal rearrangements in human AML (translocation t(8;21)(q22;q22)) and reported to participate in the oncogenic growth of t(8;21) cells [13]. This evidence concerns the gene RUVBL1 and acute myeloid leukemia.