We also identified pontin/RUVBL1 a gene which is upregulated by AML1-ETO and generated by one of the most frequent chromosomal rearrangements in human AML (translocation t(8;21)(q22;q22)) and reported to participate in the oncogenic growth of t(8;21) cells [13]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.