SPI1 and acute myeloid leukemia: In radiation-induced mouse AML, significantly higher expression of c-myc was previously reported especially in the PU.1-deficient (deletion of one copy and R235 point mutation) AMLs [33] and interestingly in therapy-related AML, abnormalities of chromosomes 5 and/or 7 accounted for 76% of all cases with an abnormal karyotype and it has been reported that AML with a −5/del(5q) have a higher expression of c-MYC [34].