Partly because of the more limited range of proteins analysed, the commonly deregulated proteins were fewer in number with just 3 being commonly deregulated in the three primary and in vivo passaged samples, Fkbp5, Tln1 and Tuba4a and just one, Fkbp5, commonly deregulated in all AML materials (cell lines, in vivo passaged MLP3 and primary AMLs). The gene discussed is TLN1; the disease is acute myeloid leukemia.