FN1 and breast cancer: Therefore, in this study, the level of FN on EV using Method 1 (AUC, 0.810; 95% CI, 0.758–0.862 vs. 0.748, 0.683–0.812, p= 0.166; Figure 4, Table 2 and 3) yielded an improved differential diagnosis of BC from all controls compared with the level of FN in plasma using Method 2 (AUC, 0.773; 95% CI, 0.721–0.834 vs. 0.684, 0.614–0.753, p= 0.091; Figure 4, Table 2 and 3).