The SIKE mRNA level was significantly reduced in human hearts with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) compared with normal hearts (Fig. 1a), as well as in aortic banding (AB)-challenged hypertrophic mouse hearts compared with sham-operated hearts (Fig. 1b). Here, SIKE1 is linked to hypertrophic cardiomyopathy.