AOPEP and cardiac hypertrophy: As expected, blocking ROS production with NAC or APO markedly reversed the cardiac hypertrophy and dysfunction induced by AB surgery in both NTG and Traf6-TG mice, as evidenced by their decreased HW/BW (Fig. 5a), LW/BW (Fig. 5b) and HW/TL ratios (Fig. 5c); normalized LVEDd, LVESd and FS values (Supplementary Fig. 4a); and reduced cross-sectional area visualized by HE staining (Fig. 5d,e) compared with mice treated with saline administration.