Second, probably, rs10505477 allele could alter the interactions between the CASC8 and its cognate gene POU5F1B (POU class 5 homeobox 1 pseudogene 1), an acknowledged tumor susceptibility gene [33], by regulating the binding of some transcription factors to promoter of POU5F1B gene. The gene discussed is CASC8; the disease is neoplasm.