Associated with germline mutations in the 5′ untranslated region of the gene Ankyrin Repeat Domain 26 (ANKRD26) on chromosome 10p12, Thrombocytopenia 2 is an autosomal dominant disorder that is characterized by moderate thrombocytopenia with or without bleeding propensity, similar to FPD/AML. The gene discussed is ANKRD26; the disease is thrombocytopenia 2.