After showing that IL-6 can transform breast stromal fibroblasts to myofibroblasts [19], we have demonstrated in the present report that this effect is sustained due to the activation of the inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop, which has been previously shown to play crucial roles in cell transformation and tumorigenesis through the induction of an epigenetic switch [17, 18]. The gene discussed is STAT3; the disease is cancer.