Interestingly, PLSCR1 overexpression impaired the ability of MCL cells to undergo autophagy induced also by serum starvation or by treatment with the mTOR inhibitors rapamycin (1 μM) and everolimus (1 μM) (Figure 4E and Supplementary Figure S2), while concomitantly improved cell responsiveness to the anti-proliferative activity of both these drugs (Supplementary Figure S2). The gene discussed is PLSCR1; the disease is mantle cell lymphoma.