Although there were no positive results in the African group, our results suggested that the APEX1 Asp148Glu polymorphism was significantly related to Pca in the subjects of mixed descent (dominant model: OR = 1.450, 95%CI = 1.081-1.943, I2 = 0.00%; per-allele analysis: OR = 1.261, 95%CI = 1.019-1.559, I2 = 32.00%), which had been demonstrated previously [32](Figure 2, Table 2). Here, APEX1 is linked to posterior cortical atrophy.