In addition, another clinical study reported a significant improvement of the long-term (i.e. 5 years) neurological outcomes of EPO-treated patients, using two consecutive doses of EPO (i.e. 5,000 IU/dose) administered at 48 hours and 72 hours following ischemic stroke [35], thus suggesting that EPO is an effective treatment for acute ischemic stroke. Here, EPO is linked to ischemic stroke.