In addition, due to the fact that tubular epithelial cell death occurred in high-salt-diet-induced nephropathy, we also examined the effects of salt-loading on Bcl-2 (B-cell lymphoma-2, an anti-apoptotic protein) activation, and the data showed that it indeed led to the phosphorylation/inactivation of Bcl-2. Here, BCL2 is linked to kidney disorder.