This study found that in breast cancer cells, silencing of integrin α5 or δ-catenin alone eradicated the cell adhesion and migration enhanced by AKR1B10; and co-silencing of both integrin α5 and δ-catenin displayed a synergistic effect, suggesting that the integrin α5 and δ-catenin both function as the downstream effectors of AKR1B10 in regulation of the adhesion and migration of breast cancer cells. Here, AKR1B10 is linked to breast cancer.