Of note, AKR1B10 promoted the adhesion, migration and invasion of MCF-7 cells in vitro, but AKR1B10 alone could not convert the non-invasive MCF-7 cells into invasive, lung metastatic cells (data not shown), suggesting that AKR1B10 may function as a promoter, but not an initiator, of breast cancer metastasis. Here, AKR1B10 is linked to breast carcinoma.