Correlative analyses using Spearman correlation indicated that the expression of AKR1B10, integrin α5 and δ-catenin was correlated to each other (Table 1); multivariate canonical correlations of AKR1B10, integrin α5 and δ-catenin expression were r=0.645 (p<0.0001) in primary breast cancer and r=0.796 (p<0.0001) in metastatic lymph nodes. The gene discussed is AKR1B10; the disease is breast cancer.