Similarly, we also found that TRPML-2 protein is expressed in all glioma specimens, with the high expression in GBM and low expression in astrocytoma grade I. Concordingly, high level of TRPML-2 mRNA and proteins were observed in high-grade U87 astrocytoma as well as in T98 and U251 GBM cell lines. Here, MCOLN2 is linked to central nervous system cancer.