The findings of the dependence of TRPML-2-mediated survival and proliferation of glioma cells to the PI3K/Akt pathway may be relevant in the view of a role of phosphoinositides (PIPs) in the regulation of TRPMLs expression and functional activity [19, 38] and on the ability of PI(3,5)P2 to activate TRPML-2 [19]. The gene discussed is AKT1; the disease is glioma.