At the beginning, we assess the value of serum haptoglobin for discriminating NSCLC patients from normal healthy controls, ROC/AUC analysis displayed a sensitivity of 0.639 (specificity of 0.881, AUC=0.809, 95% CI: 0.767–0.852, cut-off value = 1.495 mg/mL, Figure 2A). This evidence concerns the gene HP and non-small cell lung carcinoma.