These studies also provided evidence that MOv18 IgE efficacy may be mediated via anti-tumor effector cell functions in vivo: addition of PBMCs was required for the observed protective effect and this efficacy was ablated upon depletion of monocytes; monocytic infiltration was observed in tumor sections from mice treated with MOv18 IgE; and large areas of tumor necrosis were detected following MOv18 IgE treatment [122, 126]. Here, IGHE is linked to neoplasm.