Different mechanisms can lead to shedding of extracellular domains of cell surface molecules, such as the enzymatic activity of ADAM (a disintegrin and metalloproteinase) proteins, and it remains to be shown what mechanisms are involved in the generation of sGARP.[20] So far the membrane protein GARP has not been detected on other tumor cells, whereas recent transcriptome analysis suggested expression in both, breast and prostate primary tumors and cell lines [33, 34]. The gene discussed is LRRC32; the disease is neoplasm.