Several studies have reported expression of Treg specific markers such as Foxp3 (forkhead-box-protein p3), CD39, or other stromal markers like CD73 in different tumor entities (e.g. pancreatic, gastric or lung carcinoma) correlated with lymph node metastasis and poor prognosis.[6–8] In the past, our group defined an important role for the soluble form of the Treg activation marker GARP (glycoprotein A repetitions predominant, sGARP), contributing to the induction of peripheral tolerance. The gene discussed is FOXP3; the disease is metastasis.