Herein, we found a significant inhibition of T cell proliferation and effector cytokine production such as IFN-γ and IL-2 (Figure 1) resembling to the results obtained in co-culture experiments with human Treg as shown previously.[14, 15] Based on these data, we analyzed further potential phenotypical and functional similarities of melanoma cells and Treg. The gene discussed is IL2; the disease is melanoma.