In addition to baseline sCK levels, several covariates were independent risk factors for death: age (p<0.001), measured GFR (p<0.001), history of cardiovascular disease (p<0.001), serum albumin (p = 0.04) and prealbumin (p = 0.008), smoking status (p = 0.006) and proteinuria (p = 0.002) (Table 3). Here, SHC2 is linked to cardiovascular disorder.