ZMPSTE24 and hypophosphatasia: 2011). As an example, the c.1085dupT mutation in ZMPSTE24 that was reported in Old Colony Mennonites is also recently reported in Hutterites (Loucks et al. 2012). Similarly, the c.1001G>A mutation in ALPL was originally found to cause hypophosphatasia in Mennonites (Greenberg et al. 1993) and subsequently detected in at least one Hutterite infant.