Here, we found, in ERBB2 gene (EGFR family member, also known as HER2), the c.2329G>T missense mutation caused amino acid substitution (p.Val777Leu) which resulted in excessive activation of downstream signaling pathways in breast cancer, lung cancer, and other tumors (Greulich et al. The gene discussed is EGFR; the disease is lung carcinoma.