Three main immunoregulatory strategies in RA include inhibition of TNF-α, shifting immune response from Th1 that produces pro-inflammatory cytokines to Th2 that produces anti-inflammatory cytokines such as IL-10, and alteration immune responses toward IL-10 which is able to induce a skew from inflammatory to anti-inflammatory reaction (Yudoh et al., 2000 ▶). This evidence concerns the gene TNF and rheumatoid arthritis.