Monocytes, macrophages, and T and B cells lymphocytes are involved in pathogenesis of RA with increasing production of inflammatory cytokines such as tumor necrosis factor (TNF-α), interleukin (IL)-1β, and IL-6 which some of these cells lead to destructive progress of synovial cartilage and bones (Goronzy et al., 2006 ▶; Weyand et al., 2000 ▶). This evidence concerns the gene IL1B and rheumatoid arthritis.