Studies have shown that POT1-03 (rs33964002) A-allele have a close relationship with breast cancer and can decrease survival rate (Shen et al. 2012); and the polymorphism of POT1 rs7784168 was significantly associated with lower likelihood of major vessel invasion and overall survival of patients with hepatocellular carcinoma (Jung et al. 2014). Here, POT1 is linked to breast cancer.