Also, previous studies described various necrotic and apoptotic manifestations following treatment with scorpion venoms on different cancer cell lines such as massive releasing of LDH, up-regulation of caspase-3 activity, membrane blebbing, chromatin condensation and DNA degradation (Li et al. 1997; Gupta et al. 2007; Gomes et al. 2010; Zargan et al. 2011a, b, c). This evidence concerns the gene CASP3 and cancer.