VEGFA and endothelial dysfunction: 2001; Moulton 2006). On the other hand, the lack of sufficient VEGF signaling could result in endothelial dysfunction, vascular degeneration, and formation of weak, thin‐walled vasculature, which can reduce vessel compliance and increase the risk of spontaneous vessel wall rupture (Qureshi et al. 2001; Greenberg and Jin 2005).