For example, elevated levels of BNP are associated with congestive heart failure [18] and D-dimer [19] is elevated in any clinical circumstance in which both clot formation and subsequent fibrinolysis are increased, including deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, acute myocardial infarction, surgery, and trauma. The gene discussed is NPPB; the disease is pulmonary embolism.