The aims of this prospective study in consecutive patients were to assess: 1) the rate of an increase of biomarkers (BNP, D-dimer, MMP-9 and S-100β) tested with Triage Stroke Panel in patients admitted for ischemic or hemorrhagic stroke; 2) the correlation between the increase of these biomarkers and functional outcome at 120 days; 3) the risk factors for the increase of biomarkers. This evidence concerns the gene NPPB and stroke disorder.