PRRT2 and mood disorder: Figure 1 shows the trend of estimated marginal means Since the late 1990s, some drugs have been made based on the activity of PKC inhibition, while the mandatory characters to test such drugs in humans include: having the ability for PKC inhibition in areas of the brain involved in the mood disorder, evaluating this ability in more than an animal model, passing easily from Blood- Brain Barrier (BBB) and tolerating the drug absorption.