Collectively, it seems that a distinct entity might exist in which the PNPLA3 risk allele appears to be a major driver of disease progression in combination with viral infection, alcohol abuse, lifestyle (unhealthy diet and inactivity), and/or nonlifestyle (cryptogenic) causes, for example, PNPLA3-associated steatohepatitis (“PASH”) [140]. This evidence concerns the gene PNPLA3 and alcohol abuse.