Mutations in PNPLA3 (patatin-like phospholipase domain containing 3) [34, 35], TM6SF2 (transmembrane 6 superfamily member 2) [6, 36], DGAT1 (diacylglycerol O-acyltransferase 1) [37], or hypobetalipoproteinemia [38, 39] genes are not related to increased insulin resistance except for severely obese individuals in which it is associated [40]. This evidence concerns the gene TM6SF2 and hypobetalipoproteinemia.