Here, the expression level of p-STAT3 was reduced on EBI3 blocked CRCs and tumor generated from EBI3 blocked C26 cells but increased on CD45+CD3+CD8+TILs at 6 h after EBI3 blocked peptides stimulation, suggesting EBI3 regulates the tumor growth and antitumor cytotoxic T lymphocyte response by bidirectional reciprocal-regulation STAT3 signaling pathway. The gene discussed is STAT3; the disease is neoplasm.