Results found EBI3 blocking to promote Granzyme B and IFN-γ production on CD8+ TILs but did not affect T cell proliferation or EBI3+, IL-12p35+, and IL-27p28+ T cell production, which indicated EBI3 has nothing to do with iTreg in assisting CRC cells escape immune surveillance. The gene discussed is GZMB; the disease is colorectal carcinoma.