The findings that PDE10A is induced in human colon tumor cells (Li et al, 2015) and that MP‐10 halts tumor cell growth through PKG signaling and induces apoptosis (Lee et al, 2015), further add that PDE10A inhibitors may have multiple applications in obese patients with comorbid colorectal cancer. The gene discussed is PRKG1; the disease is colorectal cancer.