Beyond the two pain-inflammation conditions tested, TRPV4/TRPA1 co-involvement appears to play a role in several health-relevant conditions, such as colitis, itch, injury to airway and lungs via the inhalatory route and chronic cough28, 34, 51, 52, 53, 54, 55, 56, 57, 58. Here, TRPV4 is linked to colitis.