BMP2 and ossification of the posterior longitudinal ligament of the spine: As shown in a recent study, a forced expression of BMP2 containing the rs2273073 in C3H10T1/2 cells (mouse embryonic fibroblasts) was found to increase cell susceptibility to bone transformation similar to pre-OPLL change as well as the sensibility to mechanical stress which might play an important role during the progression of OPLL28.