In summary, we could show that rare non-synonymous MM-associated SNPs that are located in conserved domains of the RTKs EGFR, EPHA2, ERBB3, IGF1R and NTRK1 have a significant influence on OS, EFS and PFS in patients of the current study cohort and might thus be of prognostic relevance. Here, EPHA2 is linked to Miyoshi myopathy.