Given that RTKs play an important role in tumorigenesis and treatment of several cancer entities, [21, 26–29] we thus focused on the six RTK genes EGFR, EPHA2, ERBB3, IGF1R, NTRK1 and NTRK2 that were previously described to be mutated in MM and deep-sequenced their coding DNA sequence (CDS) in biopsies of 75 primary MM cases of the “Deutsche Studiengruppe Multiples Myelom” (DSMM) taken at diagnosis. Here, EGFR is linked to Miyoshi myopathy.