TP53 and cancer: It has been well reported that plant derived phytochemicals induce oxidative DNA damage in cancer cells by producing elevated level of ROS [31] which in turn induces up-regulation of p53, the critical regulator of mitochondria mediated apoptosis, inducing apoptosis by up-regulating some critical apoptotic modulators such as puma, Noxa and Bax [40, 41].