One Taiwan study found that ERCC2/XPD rs238406 CC (or GG of its antisense) instead of the AA (or TT of its antisense) genotype of 185 ESCC patients with neoadjuvant chemoirradiation followed by esophagectomy could additively increase risk of death and disease progression in cisplatin-based neoadjuvant concurrent chemoradiation therapy [34]. The gene discussed is ERCC2; the disease is esophageal squamous cell carcinoma.