The correlation analysis of SNPs and the survival time of all adenocarcinoma patients revealed that among patients of the same age and clinical stage, patients with a CC homozygous genotype of rs402710 (CLPTM1L) had longer PFS compared with CT heterozygous genotype (P < 0.05).Patients with an AA homozygous genotype of rs80270 (CDKN1A) prolong PFS compared with patients with a CC homozygous genotype (P < 0.05). The gene discussed is CDKN1A; the disease is adenocarcinoma.