In our study, PTEN (rs2299939, rs2735343), PI3K (s2699887), MDM2 (rs2279744) and P53 (rs1042522) significantly affected the chemotherapy sensitivity and survival time of lung adenocarcinoma patients, suggesting that the related genes of this pathway and the combined effects of these genes changed the tumor sensitivity to radio-chemotherapy, and then changed the survival time after treatment of NSCLC. This evidence concerns the gene PTEN and lung adenocarcinoma.