The results showed that the SNPs in XPC (rs2228000 and rs2228001), TP73 (rs2273953), MDM2 (rs2279744), PTEN (rs2299939) and DNA-PKcs (rs8178085 and rs12334811) genes significantly affected the sensitivity of lung squamous cell carcinoma to chemotherapy. The gene discussed is PRKDC; the disease is squamous cell lung carcinoma.