Zhou et al. revealed that the polymorphisms G4C14-to-A4T14 of p73 (rs2273953, rs1801173) had a positive correlation with triple-negative breast cancer (TNBC) and then found that it could be used in the treatment of TNBC32.We found that the CC homozygous genotype of the rs2273953 in the TP73 gene was sensitivity toward chemotherapy in squamous cell carcinoma and had a median survival time of 26 months compared with other genotypes (P < 0.05). This evidence concerns the gene TP73 and squamous cell carcinoma.