Together with earlier results showing that PIK3 had sensitivity to chemotherapy in adenocarcinoma and PTEN had sensitivity to radiotherapy in adenocarcinoma, these findings suggest that the polymorphisms in PTEN, PI3K, Mdm2 and p53 genes, which belong to a functionally related network, may function cooperatively in the radio-chemotherapy and survival time of adenocarcinoma. This evidence concerns the gene PTEN and adenocarcinoma.