Two of the many features of delayed anaemia following use of intravenous artesunate are initial conservation of once-infected red blood cells (preventing precipitous fall in haematocrit during treatment) and destruction of the once-infected red blood cells 7–21 days later causing severe haemolytic anaemia measured as 10 % fall in pre-treatment haemoglobin associated with haptoglobin <0.1 g/L and either an increase in LDH to >390 IL/L or a 10 % rise >7 days after start of treatment [7, 10]. This evidence concerns the gene HP and anemia (phenotype).