TP53 and acute lymphoblastic leukemia: While AneuFinder did not detect any chromosome copy number alterations in the male Lck-Cre− control thymus (Fig. 3c), all five T-ALL samples revealed clonal copy number gains of chromosomes 4, 9, 14 and 15 (Fig. 3d–h), highly similar as identified in Mps1; p53; Lck-Cre T-ALLs assessed by aCGH analysis (Fig. 1a and [15]).