TP53 and lymphoma: Interestingly, the developing lymphomas harvested from 13- and 14-week-old Mps1; p53; Lck-Cre mice showed comparable heterogeneity and aneuploidy scores to the five assessed endpoint lymphomas (Fig. 4a, compare orange circle and square to blue circles, lymphoma karyotypes in Additional file 9: Figure S6b, c), suggesting that CIN rates remain constant during tumourigenesis in our mouse model.