The direct correlation between these cytokines and the Arg64/X variant is not known, but low visfatin and high resistin concentrations are characteristic for obesity state and correlate with the risk of diabetes mellitus (El-Mesallamy et al. 2011; Savage et al. 2001; Norata et al. 2007). This evidence concerns the gene NAMPT and obesity due to melanocortin 4 receptor deficiency.