MYC and neoplasm: Studies have shown that the 8p11-p12 chromosomal region is a hotspot for genomic aberrations and that co-amplification with the MYC oncogene (8q24.21) as well as altered transcriptional patterns (hypomethylation) of genes spanning 8q12.1-q24.22, which includes SQLE, is associated with more aggressive tumours [60].