KRAS and colorectal cancer: We note that in many cases, although both panel-based approaches and our integrative genomic approach would have found a well-recognized actionable mutation, e.g. activating mutations in KRAS in colorectal cancers that are associated with lack of benefit to cetuximab or panitumumab, the comprehensive genomic profiling we applied led to the identification of additional actionable alterations in these cases that may inform alternative therapeutic options.