In a quadruple negative colon cancer case (patient P0009), expression of the EGFR ligands epiregulin and amphiregulin were elevated by a remarkable 113-fold and 29-fold, respectively, in tumor samples in comparison to the adjacent normal tissue control, therefore predicting favorable outcome in response to cetuximab treatment [34, 35]. The gene discussed is EGFR; the disease is malignant colon neoplasm.