For example, there are evidences suggest that Aβ induces different changes of CaN expression in neurons and astrocytes, and CaN A, the catalytic subunit of CaN, is proteolytically activated in AD cortex by the degradation of an autoinhibitory domain [39, 40] and which is expressed in reactive astrocytes surrounding senile plaques [41]. Here, NUP214 is linked to Alzheimer disease.