It was discovered by deep sequencing analysis that ccRCC can be further subclassified on the basis of mutations either of several transcriptional regulators, such as PBRM1 (polybromo-1), ARID1A (AT-rich interactive domain-containing protein 1A), BAP1 (BRCA1 associated protein-1), JARID2C (lysine-specific demethylase 5C), SETD2 (SET domain containing 2), or of the PTEN (phosphatase and tensin homolog)-mTOR (mammalian target of rapamycin) pathway members [11]. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.