VHL and nonpapillary renal cell carcinoma: A prominent pathological feature of ccRCC is its rich vasculature [2] due to the dysfunction of von Hippel-Lindau gene (VHL) and deregulation of hypoxia inducible factors (HIF) resulting in specific gene expression changes, which promote neoangiogenesis through vascular endothelial growth factor (VEGFs) and vascular endothelial growth factor receptor (VEGFRs) expressions [3].