EPAS1 and renal cell adenocarcinoma: [26] A further possible cause of the inverse dysregulation of HIF-1α and HIF-2α might be the defects of the genes (SETD2, JARID1C (lysine-specific demethylase 5C), UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome), etc.)of histone modification, which are known to be common in wild-type VHL RCC.