Moreover, knockdown of endogenous Oct4 expression sensitizes bladder cancer cells to cisplatin, 5-FU, doxorubicin, paclitaxel, gemcitabine, and methotrexate, but not to mitomycin C. Despite the fact that Oct4 is not induced following paclitaxel treatment, knockdown of Oct4 enhances sensitivity of bladder cancer cells to paclitaxel. The gene discussed is POU5F1; the disease is urinary bladder cancer.