INTS10 can also efficiently reduce the HBV markers in human hepatoma cell line HepG2.2.15 which constitutively produces HBV (Fig. 2j–r), and in human hepatoma cell line HepG2 which was co-transfected with the pAAV-HBV1.2 vectors (Supplementary Fig. 8). This evidence concerns the gene INTS10 and hepatocellular carcinoma.