The World Health Organization released its interim case definition for ZIKV as a person presenting with clinical symptoms: rash or fever and one or more of arthralgia, arthritis or conjunctivitis and a positive IgM with epidemiological link (probable case) or a sample positive for ZIKV RNA or IgM with a positive PRNT for ZIKV vs. other flaviviruses [256]. Here, CD40LG is linked to conjunctivitis.