To investigate a potential application of our newly characterized salicylate- and diflunisal-mediated inhibition of CBP/p300 activity, we tested the effects of various doses of salicylate and diflunisal on two AML1-ETO expressing cancer cell lines (human Kasumi-1 cells and a mouse AE9a-driven AML cell line that we generated). This evidence concerns the gene RUNX1 and acute myeloid leukemia.