Although associations between LPS-stimulatedinflammation levels and depression/anxiety also weakened after lifestyle andhealth adjustment, especially with respect to disorder status, several associationsstill remained (that is, IL-8 with remitted and current disorder, IL-8, MCP-1 andMMP2 with depressive symptom severity, and LPS-stimulated inflammation index, IL-6,IL-8, IL-10, IL-18, MCP-1, MMP2 and TNF-β with anxiety symptom severity). The gene discussed is IL18; the disease is depressive disorder.