TRIM5 and multiple sclerosis: The 11p15.4-affected genes include TRIM5 and TRIM22, known as intrinsic immune factors against retroviruses and implicated in the etiology of multiple sclerosis.58 Interestingly, a genetic pleiotropy was observed between multiple sclerosis and SZ but not BD,54 which coincides with our observation that 11p15.4 is associated with only SZ.