A combined data set of five psychiatric disorders identified genome-wide significant SNPs in four regions, including 3p21, 10q24, CACNA1C and CACNB2.10, 11 In contrast, a GWAS in a Swedish population12 reported greater involvement of the major histocompatibility complex region in SZ than in BD, consistent with the observation of Ruderfer et al.11 The miR137 variant, rs1625579, appears to conditionally influence brain function that contributes part of the risk to SZ but not to BD.13, 14 Meanwhile, rs9371601 (SYNE1), rs10994397 (ANK3) and rs12576775 (ODZ4) are likely more related to BD risk.10 This evidence concerns the gene TENM4 and Behcet disease.